107-04 ScienCell 重組人神經(jīng)營養(yǎng)蛋白-4 rhNT-4，Recombinant Human Neurotrophin-4

ScienCell 研究實(shí)驗(yàn)室（ScienCell）是一家生物技術(shù)公司，其使命是實(shí)驗(yàn)和治療用細(xì)胞和細(xì)胞相關(guān)產(chǎn)品的研究和發(fā)展。 ScienCell為研究界提供各種高質(zhì)量的正常的人類和動物細(xì)胞，細(xì)胞培養(yǎng)基和試劑，培養(yǎng)基添加因子，細(xì)胞來源的RNA，cDNA和蛋白質(zhì)。ScienCell的科學(xué)家們以改善生活質(zhì)量，實(shí)現(xiàn)細(xì)胞的能力，打擊人類退化性疾病為目的研究和開發(fā)各種細(xì)胞治療策略。ScienCell總部設(shè)在美國加利福尼亞州圣地亞哥，公司成立于1999年。

北京諾博萊德作為ScienCell品牌的特約經(jīng)銷商，為客戶提供，正規(guī)進(jìn)口，貨期穩(wěn)定，折扣好的服務(wù)標(biāo)準(zhǔn)。

107-04 ScienCell重組人神經(jīng)營養(yǎng)蛋白-4 rhNT-4，Recombinant Human Neurotrophin-4，產(chǎn)品簡介：

產(chǎn)品品牌; ScienCell

產(chǎn)品貨號：107-04

產(chǎn)品名稱：107-04 ScienCell重組人神經(jīng)營養(yǎng)蛋白-4 rhNT-4，Recombinant Human Neurotrophin-4

產(chǎn)品規(guī)格：2ug

ScienCell提供純化的、高質(zhì)量的生長因子，為您的研究助力。一些專門的信號分子，在細(xì)胞的增殖和分化中發(fā)揮核心作用。只有高純度的因子才能實(shí)現(xiàn)信號通路的高強(qiáng)度活化。 ScienCell提供的生長因子具有以下特性：高活性，少量的蛋白即有很強(qiáng)效應(yīng)；高純度，污染物少，干擾小。

107-04 ScienCell重組人神經(jīng)營養(yǎng)蛋白-4 rhNT-4，Recombinant Human Neurotrophin-4, 產(chǎn)品說明：

神經(jīng)營養(yǎng)因子-4（NT-4）是NGF家族神經(jīng)元和上皮生長因子的成員。神經(jīng)營養(yǎng)因子有六個保守的半胱氨酸殘基，參與三個二硫鍵的形成。人類NT-4與人類β-NGF，BDNF和NT-3共享48-52%氨基酸（aa）序列同一性。它分別與小鼠和大鼠NT-4 / 5共享91%和95%的同一性。成熟蛋白以同源二聚體的形式分泌，也可與BDNF或NT-3形成異二聚體。NT-4結(jié)合并誘導(dǎo)受體二聚化和TrkB的活化.NT-4促進(jìn)選定的外周和CNS神經(jīng)元的發(fā)育和存活。NT-4誘導(dǎo)的TrkB信號傳導(dǎo)增強(qiáng)NMDA受體活性并增加神經(jīng)元對興奮性毒性細(xì)胞死亡的敏感性。它還促進(jìn)角質(zhì)形成細(xì)胞的增殖，并在毛囊周期中加速毛囊消退。NT-4由活化的T細(xì)胞和粒細(xì)胞在炎癥部位分泌，有助于組織再生。

Neurotrophin-4 (NT-4) is a member of the NGF family of neuronal and epithelial growth factors. Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. Human NT-4 shares 48 - 52% amino acid (aa) sequence identity with human beta-NGF, BDNF, and NT-3. It shares 91% and 95% identity with mouse and rat NT-4/5, respectively. The mature protein is secreted as a homodimer and can also form heterodimers with BDNF or NT-3. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 promotes the development and survival of selected peripheral and CNS neurons. NT-4 induced TrkB signaling augments NMDA receptor activity and increases neuronal sensitivity to excitotoxic cell death. It also promotes the proliferation of keratinocytes and accelerates hair follicle regression during the follicular cycle. NT-4 is secreted by activated T cells and granulocytes at sites of inflammation where it contributes to tissue regeneration.

ScienCell生長添加物產(chǎn)品訂購信息：
102-01 重組人干細(xì)胞因子 rhSCF，Recombinant Human Stem Cell Factor  2ug
102-02 重組人粒細(xì)胞集落刺激因子 rhG-CSF，Recombinant Human Granulocyte Colony Stimulating Factor 2ug
102-03 重組人粒細(xì)胞巨噬細(xì)胞集落刺激因子 rhM-CSF，Recombinant Human Granulocyte Macrophage Colony Stimulating Factor 5ug
102-09 重組人巨噬細(xì)胞集落刺激因子 rhM-CSF，Recombinant Human Macrophage Colony Stimulating Factor  2ug
103-01 重組人腫瘤壞死因子-alpha rhTNF-α，Recombinant Human Tumor Necrosis Factor-alpha   10ug
103-01H 重組人腫瘤壞死因子-alpha，rhTNF--His，Recombinant Human Tumor Necrosis Factor-alpha, His 10ug
103-01v 重組人腫瘤壞死因子-alpha，Variant rhTNF-α  variant，Recombinant Human Tumor Necrosis Factor-alpha Variant 10ug
103-04 重組人B細(xì)胞激活因子 rhBAFF，Recombinant Human B Cell Activating Factor 5ug
103-08 重組人制瘤素-M227a.a. rhOSM，Recombinant Human Oncostatin-M 227a.a. 2ug
103-08T 重組人制瘤素-M209a.a.，Recombinant Human Oncostatin-M209a.a   2ug
103-09 重組人血管生成抑制因子K1-3 rhAngiostatin K1-3，Recombinant Human Angiostatin K1-3 10ug
103-12 重組人血管內(nèi)皮抑制素 rhEndostatin，Recombinant Human Endostatin    20ug
104-01 重組人成纖維細(xì)胞生長因子-acidic rhaFGF，Recombinant Human Fibroblast Growth Factor-acidic 10ug
104-02 重組人成纖維細(xì)胞生長因子-basic rhbFGF，Recombinant Human Fibroblast Growth Factor-basic 10ug
104-07 重組人角質(zhì)細(xì)胞生長因子 rhKGF-1，Recombinant Human Keratinocyte Growth Factor-1  2ug
104-09 重組人成纖維細(xì)胞生長因子-9 rhFGF-9，Recombinant Human Fibroblast Growth Factor-9  5ug
104-10 重組人角質(zhì)細(xì)胞生長因子-2 rhKGF-2，Recombinant Human Keratinocyte Growth Factor-2 5ug
104-19 重組人成纖維細(xì)胞生長因子-19 rhFGF-19，Recombinant Human Fibroblast Growth Factor-19 5ug
104-21 重組人成纖維細(xì)胞生長因子-21 rhFGF-21，Recombinant Human Fibroblast Growth Factor-21 5ug
105-01 重組人胰島素生長因子-1 rhIGF-1，Recombinant Human IGF-I 20ug
105-01B 重組人DES（1-3）胰島素生長因子-1 rhIGF-BP3，Recombinant Human DES (1-3) IGF-1  20ug
105-01B3重組人胰島素生長因子-BP3，Recombinant Human IGF-BP3 5ug
105-03 重組人longR3胰島素生長因子-1 rhLR3IGF-1，Recombinant Human Long R3 Insulin-like Growth Factor-1  20ug
105-04 重組人表皮生長因子 rhEGF，Recombinant Human Epidermal Growth Factor, 100 ug 100ug
105-05 重組人血管內(nèi)皮生長因子-165 rhVEGF165，Recombinant Human VEGF165 2ug
106-06 重組人干擾素γ rhIFN-γ，Recombinant Human Interferon-gamma  20ug
107-04 重組人神經(jīng)營養(yǎng)蛋白-4 rhNT-4，Recombinant Human Neurotrophin-4  2ug
107-08 重組人纖毛神經(jīng)營養(yǎng)因子 rhCNTF，Recombinant Human Ciliary Neurotrophic Factor  5ug
107-10 重組人神經(jīng)調(diào)節(jié)蛋白 rhBTC，Recombinant Human NRG-1 EGF-like domain  10ug
107-11 重組人ErbB3片段 rhErbB3-f，Recombinant Human ErbB3 Fragment  5ug
107-12 重組人β動物纖維 rhBTC，Recombinant Human Betacellulin 5ug
108-02 重組人骨形成蛋白-2 rhBMP-2，Recombinant Human Bone Morphogenetic Protein-2 2ug
108-04 重組人骨形成蛋白-4 rhBMP-4，Recombinant Human Bone Morphogenetic Protein-4 2ug
108-07 重組人骨形成蛋白-7 rhBMP-7，Recombinant Human Bone Morphogenetic Protein-7 2ug
108-08 重組人骨保護(hù)素 rHuOPG-Fc，Recombinant Human Osteoprotegerin/Fc Chimera  10ug
108-09 重組人NOGGIN蛋白 rhNOGGIN，Recombinant Human NOGGIN  5ug
301-01 重組人生長激素 rhGF，Recombinant Human Growth Hormone 20ug